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在發(fā)展中求生存,不斷完善,以良好信譽(yù)和科學(xué)的管理促進(jìn)企業(yè)迅速發(fā)展INTRODUCTIONTheN-α-Fmoc-α-aminoisobutyricacidderivative(Aib)isadifficultderivativeforcouplinginSPPSduetoitssecondmethylgroupontheα-carbonthatinterfereswiththecouplingreaction(Figure1).However,itcanbefoundinanumberofbiologicallyrelevantcompo...
查看詳情INTRODUCTIONTheAKR/Grossmurineleukemiaviruses(MuLV)areC-typeretrovirusesthatcausethedevelopmentofleukemiainAKR(H-2k)mice.1Type-specificantiretroviralcytotoxicT-lymphocyte(CTL)responseshavebeenreportedthatallowdifferentiationbetweeninfection...
查看詳情INTRODUCTIONInthedevelopmentofantibodiesdirectedagainstspecificpeptidesequences,T-helperepitopesareoftentaggedontothepeptidesequencetoaidinthestimulationoftheimmuneresponse.OnesuchsequenceistheuniversalPanHLADR-bindingepitope(PADRE).Synthes...
查看詳情INTRODUCTIONOnechallengefacingpeptidesynthesisisthe-lactamformationofarginine(Figure1).Theformationof-lactamoccurswhentheinternalnitrogenoftheguanidineattackstheactivatedester,irreversiblyformingthelactamring.Thisreactioniscompetitivewithpe...
查看詳情INTRODUCTIONOnepotentialissueinpeptidesynthesisisracemizationofcysteineandhistidine.Thisisaconcernformicrowavepeptidesyntheisbecauseoftheelevatedtemperaturesduringdeprotectionandcoupling.Studieshaveshownthatloweringthetemperatureto50°Cdurin...
查看詳情INTRODUCTIONVIP(vasoactiveintestinalpeptide),apeptidehormone,hasbeenimplicatedinanumberofbiologicalprocessesincluding:increasingdigestivesystemmotility,stimulatingpepsinogensecretion,controllingthemammaliancircadiantimekeepingmachinery,regu...
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